TJ Pemberton (2015) "Consanguinity and genomic sharing in human evolutionary inference" in NA Rosenberg and R Nielsen (eds) Human Population Genetics II Series, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London.

Outline: Identity by descent mechanism – Identity by descent patterns are shaped by population history and cultural processes – The inbreeding coefficient estimates identity by descent levels in individual genomes – Long runs of homozygous genotypes reflect autozygosity (homozygosity for identical by descent haplotypes) – Autozygosity patterns vary across populations and elevate levels of harmful variation carried in homozygous form – Autozygosity levels are an important determinant of many monogenic and polygenic traits and diseases.

[ Lecture ] [ Series ] [ Collection ]